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2025
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09
Solving the purification problem of creatine mother liquor: The solution of electrodialysis technology
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Creatine (C₄H₉N₃O₂) is a nitrogen-containing organic acid naturally present in vertebrates, especially abundant in muscle tissue. It can provide energy for muscle and nerve cells, relieve fatigue, enhance muscle elasticity, and promote protein synthesis. It also has functions such as regulating blood lipids and blood sugar and anti-aging, and is widely used in sports nutrition, health food and medical fields.
During the production of creatine, a mixture of creatine and inorganic salts (such as sodium chloride) often remains in the mother liquor. Traditional separation methods are inefficient, costly and prone to introducing contamination. Therefore, environmentally friendly purification technologies are urgently needed. Electrodialysis, as a membrane separation process, is particularly suitable for the separation and purification of such systems because it can achieve selective separation based on the charged characteristics of substances. The anion and cation exchange membranes in the device are alternately arranged to form a series of fresh water chambers and concentrated water chambers. Under the action of an electric field, charged ions undergo migration: cations move towards the cathode, anions move towards the anode, and enter the concentrated water chamber through the corresponding membrane structure, thereby separating and concentrating the ions in the raw liquid.
The key to the purification of creatine lies in taking advantage of the property that creatine is electrically neutral at its isoelectric point (pI), while inorganic salts remain in an ionized state. By adjusting the pH of the mother liquor to the isoelectric point of creatine, the creatine molecules become neutral and are not affected by the electric field. Inorganic salt ions (such as Na⁺ and Cl⁻) migrate directionally in the electric field, pass through the ion-exchange membrane and enter the concentrated water chamber, thereby achieving separation from creatine. In actual operation, the mother liquor is pumped into the electrodialysis system and operates under the set pH and electric field conditions. Creatine is mainly retained in the fresh water chamber, while inorganic salts are concentrated in the concentrated water chamber. Ultimately, a high-purity creatine solution can be obtained from the fresh water chamber. After further crystallization and drying, the finished product can be obtained. The inorganic salts in the concentrated water chamber can also be recycled and reused, which meets the requirements of resource recycling and green production.
Electrodialysis technology has the advantages of simple operation, low energy consumption, no need to add chemical reagents, and environmental friendliness. It significantly improves product purity, avoids pollution, and is suitable for large-scale production. With the continuous development of membrane materials and process optimization technologies, the application of electrodialysis in the separation and purification of creatine and other biochemical products will continue to expand, providing reliable technical support for the green manufacturing of high-purity creatine.
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